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THE SCIENCE LIBRARY

Authority you can check.

We don't ask you to take our word for it. Below is our full reference library: every peer-reviewed study behind our programs, cited, dated, and linked for you to read. Organized by molecule class, with evidence strength labeled honestly.

Weight Management, GLP-1 (GLP-1 therapy)STRONG EVIDENCE5 studies

Semaglutide and cardiovascular outcomes in obesity without diabetes (SELECT)

New England Journal of Medicine · 2023

Once-weekly GLP-1 therapy in adults with overweight or obesity (STEP 1)

New England Journal of Medicine · 2021

Continued GLP-1 therapy vs placebo on weight-loss maintenance (STEP 4)

JAMA · 2021

Two-year effects of GLP-1 therapy in adults with obesity (STEP 5)

Nature Medicine · 2022

Efficacy and safety of GLP-1 therapy for weight loss: systematic review & meta-analysis

Frontiers in Pharmacology · 2022

Weight Management, GIP/GLP-1 (dual-incretin therapy)STRONG EVIDENCE4 studies

Cardiovascular outcomes of semaglutide and tirzepatide in clinical practice

Nature Medicine · 2025

dual-incretin therapy once weekly for the treatment of obesity (SURMOUNT-1)

New England Journal of Medicine · 2022

dual-incretin therapy after intensive lifestyle intervention (SURMOUNT-3)

Nature Medicine · 2023

dual-incretin therapy for obesity treatment and diabetes prevention (SURMOUNT-1, 3-yr)

New England Journal of Medicine · 2025

NAD⁺ / Cellular & LongevityMODERATE EVIDENCE6 studies

Human data is on NAD⁺ precursors (NMN/NR).

NAD+ precursor supplementation in human ageing: clinical evidence and challenges

Nature Metabolism · 2025

Nicotinamide riboside on NAD+ levels, cognition and recovery in long-COVID (RCT)

eClinicalMedicine · 2025

Chronic nicotinamide riboside elevates NAD⁺ in middle-aged & older adults

Nature Communications · 2018

NMN supplementation & NAD⁺ metabolism: randomized, double-blind, placebo-controlled trial

Scientific Reports · 2023

Chronic NMN elevates blood NAD⁺ and alters muscle function in older men

npj Aging · 2022

Safety and antiaging effects of NMN in human clinical trials: an update

Frontiers in Aging · 2023

antioxidant supportMODERATE EVIDENCE3 studies

Effects of oral antioxidant support on systemic oxidative-stress biomarkers (RCT)

J. Alternative & Complementary Medicine · 2011

Oral antioxidant support as a skin-lightening agent: multicenter RCT

J. Clinical & Aesthetic Dermatology · 2021

Long-term antioxidant support supplementation & oxidative damage: RCT

Antioxidants · 2022

Vitamin B12MODERATE EVIDENCE3 studies

Evidence supports correction of deficiency, not benefit in non-deficient people.

Vitamin B12 supplementation on cognition, mood & fatigue: systematic review & meta-analysis

Nutrients · 2021

Effects of B12 on neurologic & cognitive function in older people (RCT)

American Journal of Clinical Nutrition · 2015

Neurological sequelae of vitamin B12 deficiency: systematic review & RCT

Cureus · 2025

Cognitive-support compoundSTRONG EVIDENCE2 studies

Multimodal randomized fMRI of a cognitive-support compound in the human brain (RCT)

Radiology · 2016

Neurometabolic mechanisms for memory enhancement & neuroprotection, cognitive-support compound

Progress in Neurobiology · 2012

Hormone Support (provider-guided)STRONG EVIDENCE5 studies

The Women’s Health Initiative randomized trials and clinical practice: a review

JAMA · 2024

Menopausal hormone therapy and cardiovascular disease in women with vasomotor symptoms (WHI secondary analysis)

JAMA Internal Medicine · 2025

Menopausal symptoms & treatment effects of estrogen plus progestin (WHI, RCT of 16,608 women)

Obstetrics & Gynecology · 2005

Health-related quality of life after combined HRT: randomised controlled trial (WISDOM)

BMJ · 2008

Hormone replacement therapy: clinical overview & evidence

StatPearls (NCBI Bookshelf) · 2024

ED Support, provider-guided optionsSTRONG EVIDENCE3 studies

Once-a-day ED medication options in men with ED naïve to PDE5 inhibitors: RCT

J. Sexual Medicine · 2011

PDE5 inhibitors in the management of erectile dysfunction: systematic review

Reviews in Urology · 2013

ED medication options daily vs on-demand for ED: long-term meta-analysis (6 RCTs)

Translational Andrology & Urology · 2020

Hair Restoration, provider-guided optionsSTRONG EVIDENCE3 studies

Topical combination therapy for androgenetic hair loss, clinical study

Archives of Dermatological Research · 2025

Low-dose topical combination vs single agent for hair regrowth, double-blind trial

J. Dermatological Treatment · 2018

Topical combination vs monotherapy for hair restoration, systematic review & meta-analysis of RCTs

Frontiers in Medicine · 2025

growth-peptide support (GHRH analog)PRELIMINARY2 studies

Growth hormone secretagogues: history, mechanism & clinical development

JCSM Rapid Communications · 2020

growth-peptide support: a better approach to adult-onset growth hormone insufficiency?

Clinical Interventions in Aging · 2008

Growth-hormone-axis peptideSTRONG EVIDENCE2 studies

Strongest peptide evidence, FDA-regulated for HIV lipodystrophy.

Effect of tesamorelin on visceral fat & liver fat: randomized clinical trial

JAMA · 2014

growth-axis peptide improves fat quality independent of fat quantity (Phase 3 data)

J. Clinical Endocrinology & Metabolism · 2021

Growth-peptide blendPRELIMINARY2 studies

Growth hormone secretagogues: history, mechanism & clinical development

JCSM Rapid Communications · 2020

Therapeutic peptides in aesthetic, metabolic & endocrine conditions: review

Int. J. Molecular Sciences · 2026

Mitochondrial-support peptideMODERATE EVIDENCE3 studies

mitochondrial peptide is an exercise-induced regulator of aging metabolic homeostasis & physical capacity

Nature Communications · 2021

Mitochondria-derived peptide mitopep: effects & mechanisms in stress, metabolism & aging

J. Translational Medicine · 2023

mitochondrial peptide promotes metabolic homeostasis & reduces insulin resistance

Cell Metabolism · 2015

Telomere-support peptidePRELIMINARY1 study

Peptides for mitochondrial health & cellular aging: mechanistic review

J. Translational Medicine · 2023

copper peptide (copper tripeptide)PRELIMINARY1 study

Therapeutic peptides in aesthetic conditions: copper peptide, collagen & skin remodeling (review)

Int. J. Molecular Sciences · 2026

Intimacy peptide supportSTRONG EVIDENCE1 study

Options discussed during your provider visit

Therapeutic peptides review, melanocortin pathway & intimacy support

Int. J. Molecular Sciences · 2026

Calm & clarity nasal peptidesPRELIMINARY1 study

Evidence predominantly from Russian clinical research.

Therapeutic peptides in endocrine & neurologic conditions: review (calm peptide/clarity peptide class)

Int. J. Molecular Sciences · 2026

Published, peer-reviewed research on each molecule class, provided for education. Studies describe the compound generally and are not claims about any specific compounded product. Rx programs require an online visit with a licensed provider · results vary.